Treatment of advanced neuroblastoma with i-131 meta-iodobenzylguanidine
نویسندگان
چکیده
منابع مشابه
Dose calculations for [(131)i] meta-iodobenzylguanidine-induced bystander effects.
UNLABELLED Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment. METHODS Using the Vynckier - Wambersie dose point kernel, a model for dose rate evaluation was created allowing for calculation of ab...
متن کاملDisseminated malignant phaeochromocytoma: localisation with iodine-131-labelled meta-iodobenzylguanidine.
Meta-iodobenzylguanidine, a guanethidine analogue, is a newly synthesised substance capable of imaging the adrenal medulla. In a woman in whom phaeochromocytoma has been diagnosed iodine-131-labelled metaiodobenzylguanidine was given intravenously; gamma-camera images showed bilateral adrenal tumours and uptake corresponding to bone and liver metastases. 131I-meta-iodobenzylguanidine is effecti...
متن کاملI-131 MIBG Therapy for Advanced Stage III & IV Neuroblastoma
Radio-labelled MIBG therapy has been tried in the treatment of advanced stage III and IV neuroblastoma in an attempt to improve patients outcome. The use of radiolabelled MIBG to treat neuroblastoma has arisen from the high sensitivity and specificity of in vivo MIBG imaging for detection of primary and metastatic tumours. Although, clinical trials have been performed to determine the role of M...
متن کاملRole of 131-I MIBG Therapy in the Treatment of Advanced Neuroblastoma.
INTRODUCTION Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most extracranial malignant solid tumor of childhood. Many therapeutic strategies has evolved over the last 20 years, based upon work by international cooperative groups and smaller cohort studies. Novel therapies to improve initial disease response and treatment of minimal residual disease are required to i...
متن کاملDevelopment of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors.
PURPOSE The suitability of neuroblastoma patients for therapy using radiolabeled meta-iodobenzylguanidine (MIBG) is determined by scintigraphy after the administration of a tracer dose of radioiodinated MIBG whose uptake is dependent upon the cellular expression of the noradrenaline transporter (NAT). As a possible alternative to gamma camera imaging, we developed a novel molecular assay of NAT...
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ژورنال
عنوان ژورنال: Cancer
سال: 1991
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19910215)67:4<922::aid-cncr2820670411>3.0.co;2-d